Robust evidence from randomised controlled trials and meta-analyses supports the efficacy of intranasal esketamine in reducing depressive symptoms in adults with TRD, including those with severe and refractory illness . A key clinical advantage is its rapid onset of action, often producing symptomatic improvement within hours to days, compared to weeks for conventional antidepressants . Esketamine is typically administered under supervision in combination with an oral antidepressant, following an induction and maintenance schedule, reflecting both efficacy and safety considerations . Long-term studies further demonstrate sustained benefits with an acceptable safety profile when delivered within structured clinical settings .

In Australia, regulatory frameworks emphasise specialist-led delivery, with psychiatrists responsible for patient selection, prescribing, and monitoring due to the medication’s Schedule 8 status and potential risks . This underscores the importance of specialised centres capable of providing comprehensive assessment, medical oversight, and multidisciplinary care.

Within this context, Therapeutic Brain Stimulation (TBS) Melbourne is well positioned to deliver esketamine treatment as part of an integrated, evidence-based approach to TRD. Leveraging expertise in neuromodulation therapies such as transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT), TBS Melbourne offers a highly specialised environment for patient selection, protocol-driven administration, and outcome monitoring. Such centres play a critical role in translating emerging biological treatments into safe, scalable clinical practice, ensuring that patients with complex and refractory depression have access to innovative and potentially life-changing interventions.

On receiving a referral from your GP or Psychiatrist, our credentialled Psychiatrists assess the patient for suitability of Medicare Funded Esketamine Treatments. If found suitable, the treatment can commence based on the clinic processes and protocols. The Referral Form is attached below. Alternatively the referral can be emailed to admin@camberwellspecialists.com.au